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Clare Bryant

Subject groups/Research projects

Health and Medicine:

Research Interests

We use multidisciplinary approaches to understand how bacteria are detected by the host (through Pattern Recognition Receptors (PRRs)) and how pathogen detection links to inflammatory diseases such as allergies. The host has many Pattern Recognition Receptors (PRRs), such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs), that detect bacteria, such as Salmonella entericia serovar Typhimurium, and their associated molecules (such as endotoxin). We are studying which PRRs detect S. Typhimurium to drive an adaptive immune responses focussing on the NLRs and their effector mechanisms with the ultimate aim of identifying new vaccines or anti-microbials to control infectious disease in man and animals.